Notch signaling has differing effects on subpopulations of retinal progenitor cells in zebrafish retinal development
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these ...
متن کامل21-P008 Role of Notch signaling in retinal development
During retinal development, six different neuronal classes and one glial cell type arise in a conserved, temporal sequence from multipotent, cycling retinal progenitor cells (RPCs). Developing tissues, such as the retina, are exquisitely sensitive to timing of Notch signaling. Interestingly, removal of Notch1 during retinal development resulted in cell cycle exit and overproduction of photorece...
متن کاملUltrastructural Study of Cadmium Effects on Photoreceptors and Ganglionic Cells of Retinal Layer in Mice Embryo
Purpose: In this study, TEM was used to asses the ultra structural effects of Cd on Photoreceptor and Ganglionic cells of mouce retinal layer. Materials and Methods: 30 mice hi1Vebeen used in three groups (experimental I, II & control). On 9th day of gestation, experimental groups have received a single IP injection of Cadmium- chlorid (Cd C12) solution in saline, 3 mg/kg and 5 mg/kg respectiv...
متن کاملNotch signaling functions in retinal pericyte survival.
PURPOSE Pericytes, the vascular cells that constitute the outer layer of capillaries, have been shown to have a crucial role in vascular development and stability. Loss of pericytes precedes endothelial cell dysfunction and vascular degeneration in small-vessel diseases, including diabetic retinopathy. Despite their clinical relevance, the cellular pathways controlling survival of retinal peric...
متن کاملCirculating mononuclear progenitor cells: differential roles for subpopulations in repair of retinal vascular injury.
PURPOSE We examined effect on retinal vascular homing of exogenous CD34(+) and CD14(+) progenitor cells using mouse models of chronic (streptozotocin [STZ]-induced diabetes) and acute (ischemia-reperfusion [I/R]) ocular vascular injury. METHODS STZ-treated mice of short or long duration (≤4, ≥11 months) diabetes, along with age- and sex-matched controls, were given intravitreous injections of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2008
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2008.05.233